Patient with a validated indication for colonoscopy for colorectal lesions
Patients with a single colorectal lesion to be resected by ESD according to European recommendations.
Patients with a colorectal neoplastic lesion (≥3 cm)
Patients taking anticoagulants (acetylsalicylic acid \>300 mg/day) or antiplatelet agents (clopidogrel, prasugrel, ticagrelor, clopidogrel) and managed according to European recommendations for ESD (including patients who may require heparin replacement)
Written consent signed after clear, fair, and understood information.
Patients with social security coverage.
You may not be if
Patients who may have an allergic reaction to the substances of PuraStat®.
Patients with severe fibrosis
Patients with a history of familial colorectal polyposis (familial adenomatous, Lynch syndrome, Peutz-Jeghers syndrome)
Patients with a score ASA greater than or equal to 4 or 5
Patients with a platelet count of 50,000/mm3
Patients with acquired (non-medicated) or inherited bleeding disorders
Patients who are being treated with acetylsalicylic acid but whose treatment is discontinued at the time of the procedure (therapeutic window)
Patients with advanced cancer or inflammatory bowel disease, including ulcerative colitis (with colonic involvement)
Contraindication to general anesthesia
Patients with a mental disorder, drug addiction, alcoholism, etc.
Pregnant women or women wishing to become pregnant during the study
Patients already participating or scheduled to participate in other clinical trials
Lesion that has been previously resected by mucosectomy
Patient with an initial metastatic lesion prior to colonoscopy.
