Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Nykode Therapeutics ASA
With
Genentech, Inc.
Vaccibody AS
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Tumor types: melanoma, NSCLC, RCC, UC, HNSCC, TNBC, gastric/GEJ cancer, cervical, anal, or MSI-high tumors. Additionally up to 15 subjects with other locally advanced or metastatic solid tumor types not listed above.
Signed Informed Consent Form
Age ≥18 years at time of signing the Informed Consent Form
Ability to comply with the trial protocol
ECOG Performance Status of ≤ 1: Note: If ECOG Performance Status at Screen 2B assessment was performed \> 7 days prior to VB10.NEO start date, it needs to be re-assessed on C1D1 prior to administration of VB10.NEO and remain ≤ 1
GRIm score ≤ 1 at Screen 1, this only applies for subjects initially screened under protocol version 5
Adequate hematologic and end-organ function, defined by the following laboratory test results, obtained within 7 days prior to initiation of trial treatment:
ANC ≥1.5 × 109/L (1500/µL) Must be met without administration of growth factors within 2 weeks prior to treatment start date.
Lymphocyte count ≥0.5 × 109/L (500/µL)
Platelet count 100-450 × 109/L (100,000 - 450,000/µL) Must be met without administration of platelet transfusion within 2 weeks prior to treatment start date.
Hemoglobin ≥90 g/L (9 g/dL) Must be met without erythropoietin dependency and without red blood cell transfusion within 2 weeks prior to treatment start date.
AST and ALT ≤3 × ULN
Alkaline phosphatase (ALP) ≤2.5 × ULN, with the following exceptions:
Subjects with documented liver or bone metastases: ALP ≤5 × ULN
Total bilirubin ≤1.5 × ULN with the following exception:
Subjects with known Gilbert disease: total bilirubin ≤3 × ULN
Measured or calculated creatinine clearance ≥50 mL/min (according to the Cockcroft-Gault formula)
Albumin ≥25 g/L (2.5 g/dL)
For subjects not receiving therapeutic anticoagulation: International Normalized Ratio (INR) and activated partial thromboplastin time (aPTT) ≤1.5 × ULN
For subjects receiving therapeutic anticoagulation: stable anticoagulant regimen
Female subjects of childbearing potential must have a negative serum pregnancy test result within 72 hours prior to initiation of trial treatment.
Female subjects of childbearing potential must agree to use a highly effective form of contraception during treatment and for at least 90 days after the final dose of VB10.NEO, and for 5 months after the final dose of atezolizumab, whichever occurs later. Highly effective forms of contraception include:
combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation: oral, intravaginal, transdermal
progestogen-only hormonal contraception associated with inhibition of ovulation: oral, injectable, implantable
intrauterine device
intrauterine hormone-releasing system
bilateral tubal occlusion
vasectomized partner
sexual abstinence (defined as refraining from heterosexual intercourse during the entire period of risk associated with the trial treatments. The reliability of sexual abstinence needs to be evaluated in relation to the duration of the clinical trial and the preferred and usual lifestyle of the subject. Periodic abstinence \[calendar, symptothermal, post-ovulation methods\], withdrawal \[coitus interruptus\], spermicides only, and the lactational amenorrhea method are not acceptable methods of contraception).
For men with a female partner of childbearing potential or pregnant female partner: agreement to remain abstinent (refrain from heterosexual intercourse) or use a condom during the treatment period and for at least 28 days after the final dose of trial treatment to avoid exposing the embryo, and agreement to refrain from donating sperm.
You may not be if
Pregnant or breastfeeding, or intending to become pregnant during the trial or within 90 days after the last dose of VB10.NEO or 5 months after the last dose of atezolizumab, whichever occurs later
Significant cardiovascular disease such as, but not limited to, New York Heart Association Class III or IV cardiac disease, myocardial infarction within the last 6 months, unstable arrhythmias, or unstable angina
QT interval corrected through use of Fridericia's formula (QTcF) \>470ms demonstrated by at least 2 electrocardiograms (ECGs) \>30 minutes apart
Clinically significant liver disease including active viral, alcoholic, or other hepatitis, cirrhosis, and inherited liver disease or current alcohol abuse
Positive hepatitis B surface antigen (HBsAg) test at screening
Subjects with past or resolved hepatitis B infection (defined as having a negative HBsAg test and a positive IgG antibody to hepatitis B core antigen) are eligible.
Positive hepatitis C virus (HCV) antibody test at screening
Subjects positive for HCV antibody are eligible only if polymerase chain reaction is negative for HCV ribonucleic acid (RNA)
Positive human immunodeficiency virus (HIV)-1 test at screening
Active tuberculosis
Any other diseases, metabolic dysfunction, physical examination finding, and/or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or may render the subject at high risk from treatment complications
Known primary immunodeficiencies
Active, or history of, autoimmune disease or immune deficiency, including, but not limited to, myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, antiphospholipid antibody syndrome, Wegener granulomatosis, Sjögren syndrome, Guillain-Barré syndrome, or multiple sclerosis, with the following exceptions:
Subjects with a history of autoimmune-related hypothyroidism who are on thyroid replacement hormone are eligible for the trial.
Subjects with controlled Type 1 diabetes mellitus who are on an insulin regimen are eligible for the trial.
Subjects with eczema, psoriasis, lichen simplex chronicus, or vitiligo with dermatologic manifestations only (e.g., subjects with psoriatic arthritis are excluded) are eligible for the trial provided all of the following conditions are met:
Rash must cover \<10% of body surface area
Disease is well controlled at baseline and requires only low potency topical corticosteroids
No occurrence of acute exacerbations of the underlying condition requiring psoralen plus ultraviolet A radiation, methotrexate, retinoids, biologic agents, oral calcineurin inhibitors, or high potency or oral corticosteroids within the previous 12 months
History of severe allergic anaphylactic reactions to chimeric or humanized antibodies or fusion proteins.
Known hypersensitivity to Chinese hamster ovary cell products or to any component of the atezolizumab formulation.
Known allergy or hypersensitivity to any component of the VB10.NEO formulation.
History of idiopathic pulmonary fibrosis, pneumonitis (including drug-induced), organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia, etc.), or evidence of active pneumonitis on imaging conducted for tumor assessment at screening
History of radiation pneumonitis in the radiation field (fibrosis) is permitted
History of drug-induced pneumonitis that was asymptomatic (defined by radiographic findings only) and reversible (without any anti-inflammatory therapies) is permitted.
Severe infection within 28 days prior to Cycle 1, Day 1, including, but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia
Subjects receiving prophylactic antibiotics (e.g., to prevent a urinary tract infection or chronic obstructive pulmonary disease \[COPD\] exacerbation) are eligible for the trial.
Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures (once monthly or more frequently)
Subjects with indwelling catheters (e.g., PleurX) are allowed.
Uncontrolled or symptomatic hypercalcemia (ionized calcium \>1.5 mmol/L, calcium \>12 mg/dL, or corrected calcium \>ULN)
Major surgical procedure within 28 days prior to Cycle 1, Day 1, or anticipation of need for a major surgical procedure during the course of the trial
Prior allogeneic stem cell or solid organ transplantation
Treatment with systemic immunostimulatory agents (including, but not limited to, interferon and IL-2) within 28 days or 5 drug-elimination half-lives (whichever is longer) prior to Cycle 1, Day 1
Treatment with systemic immunosuppressive medications (including, but not limited to, prednisone \>7.5 mg/day, cyclophosphamide, azathioprine, methotrexate, thalidomide, and tumor necrosis factor-alpha \[TNF-α\] antagonists) within 2 weeks prior to Cycle 1, Day 1 with the following exceptions:
Subjects who received acute, low-dose systemic immunosuppressant medication or a one-time pulse dose of systemic immunosuppressant medication (e.g., 48 hours of corticosteroids for a contrast allergy) are eligible for the trial after medical monitor confirmation has been obtained
Subjects who received mineralocorticoids (e.g., fludrocortisone), corticosteroids for COPD or asthma, or low-dose corticosteroids for orthostatic hypotension or adrenal insufficiency are eligible for the trial.
Treatment with investigational therapy within 28 days prior to Cycle 1, Day 1
Live, attenuated vaccines are prohibited within 28 days prior to Cycle 1, Day 1, during atezolizumab treatment, and for 5 months after the final dose of atezolizumab
Vaccination with an approved COVID-19 vaccine that does not contain live, attenuated virus is permitted
Clareo Health | Study of VB10.NEO in Combination With Atezolizumab in Solid Tumors
