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Second Affiliated Hospital Zhejiang University School of Medicine
Postoperative hyperalgesia (POH) is a paradoxical clinical state of increased sensation of pain or increased sensitivity to non-painful stimuli at the site of surgery or at a surrounding area that was not directly injured. Opioid-induced hyperalgesia (OIH) and nociceptive-induced hyperalgesia (NIH) are the two main causes of POH.N-methyl-D-aspartate receptor (NMDAR) activation plays a central role in the development of POH.S-ketamine，which is a NMDA-receptor antagonist,has been on the market in china since 2019.The aim of this study is to evaluate the effects of S-ketamine on POH and chronic postoperative pain after video-assisted thoracic surgery.
Age
18 - 65 years
Sex
ALL
Healthy Volunteers
No
Second affiliated Hospital School of Medicine,Zhejiang University
Hangzhou, Zhejiang, China
Start Date
August 17, 2021
Primary Completion Date
December 30, 2021
Completion Date
April 30, 2022
Last Updated
September 29, 2021
92
ESTIMATED participants
S-ketamine
DRUG
saline
DRUG
Lead Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
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