Effects of Online App Weight Loss Programs on Liver Health in Obese Adults

Exclusion Criteria

• •Self-reported presence of uncontrolled cardiac, renal, endocrine, pulmonary, biliary, pancreatic, gastrointestinal, or neurological disorders or cancer (except for non-melanoma skin cancer) that may affect the subject's ability to adhere to the study protocol and/or affect study outcomes as assessed by the PI.
• •Self-reported type 1 diabetes.
• •History of gastrointestinal surgery for weight reducing purposes.
• •Participation in a weight loss trial or a program/service intended to alter body weight (e.g., Noom, Weight Watchers); medications, dietary supplements or products that affect weight loss, nutrient absorption, appetite and satiety; or weight loss or gain ≥10 lb (4.5 kg) within 6 mo of Day -7.
• •Extreme dietary habits (e.g., Atkins diet, very high protein, intermittent fasting) or eating disorder.
• •Female who is pregnant, planning to be pregnant during the study period, lactating, or is of childbearing potential and is unwilling to commit to the use of a medically approved form of contraception throughout the study period. The method of contraception must be recorded.
• •Female with prior medical diagnosis of premenstrual syndrome or premenstrual dysphoric disorder.
• •Unstable use of hormonal contraceptives, anti-hypertensive medication, medications for mental or emotional disorders, or thyroid hormones within 90 d of Day -7.
• •Exposure to any non-registered drug product within 30 d of Day -7.
• •Recent history of (within 12 mo of Day -7) or strong potential for alcohol or substance abuse. Alcohol abuse defined as \>14 drinks per week (1 drink = 12 oz beer, 5 oz wine, or
• •1½ oz distilled spirits).
• •ALT or AST \> 5 x ULN at baseline.