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Study Comparing Local/ MAC Anesthesia in Lumbar Decompression | Clinical Trials | Clareo Health

RECRUITINGEARLY_PHASE1

Study Comparing Local/ MAC Anesthesia in Lumbar Decompression

Randomized Study Comparing Local/ MAC Anesthesia to General for 1-3 Level Lumbar Decompressions

NCT04992572•Stanford University

Summary

Explore efficacy, complications, and other factors associated with anaesthetic choice- To evaluate the efficacy of local + MAC as an alternative anesthetic to general anesthesia and to analyze patients' outcomes and experiences.

Detailed Description

100 Patients ages 40-95 with lumbar stenosis to be decompressed are randomized to undergo the procedure with either general anesthesia or local anesthetic with MAC. Participants will be randomized to either group 1 General anesthesia or group 2 Local + MAC anesthetic group. Group 1: General Anesthesia: Medically induced unconsciousness that suppresses reflexes and requires intubation (a tube inserted through the mouth and into the airway) to assist in breathing. Group 2: Local + MAC: Local anesthetic (lidocaine) injected into the site of the incision/dissection with additional IV medication (Propofol) to achieve a state in which the patient is generally aware, but relaxed

Eligibility

Age

40 - 95 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients with lumbar stenosis to be decompressed over 1-3 segments
•Ages 40-95
•Appropriate for general anesthesia

Exclusion Criteria

•Planned significant nerve root retraction
•Previous fusion operation
•Unable to comply with follow up
•Patients with daily morphine equivalents or more 100mg
•Patients with a known hypersensitivity to propofol or any of DIPRIVAN Injectable Emulsion components.
•Patients with allergies to eggs, egg products, soybeans or soy products.

Locations (2)

Outpatient Surgery Center/Stanford Spine Clinic

Redwood City, California, United States

Stanford Outpatient surgery center

Redwood City, California, United States

Key Dates

Start Date

December 1, 2021

Primary Completion Date

December 31, 2026

Completion Date

December 31, 2028

Last Updated

March 20, 2026

Enrollment

100

ESTIMATED participants

Conditions

Lumbar Spinal Stenosis

Interventions

Propofol Injection

DRUG

Lidocaine Hydrochloride, Injectable

DRUG

Contacts

Sarah Miller, MAS

CONTACT

650-725-7984 sarahmi@stanford.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 20, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Study Comparing Local/ MAC Anesthesia in Lumbar Decompression

Inclusion Criteria

Exclusion Criteria

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