Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Ohio State University Comprehensive Cancer Center
PRIMARY OBJECTIVE:
I. To evaluate the impact of anesthetic agent on inflammation and immunosuppression among patients undergoing abdominal cancer surgery.
SECONDARY OBJECTIVE:
I. To determine the impact of anesthetic choice on short-term anesthetic and surgical outcomes.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients undergo surgical resection with TIVA.
ARM II: Patients undergo surgical resection with inhaled volatile anesthetics.
After completion of study treatment, patients are followed up for up to 2 years.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Adults: ≥18 years old on the day of consent
Non-metastatic pancreatic adenocarcinoma
Able to provide consent
ECOG performance status of 0 or 1
Women of childbearing potential (WOCBP) must have a negative urine or serum pregnancy test for the patient at the time of surgery.
Ability to understand and the willingness to sign a written informed consent document.
You may not be if
Previous identified allergy or hypersensitivity to any component of the study treatment
Allergies to eggs, egg products, soybeans, or soy products
Personal or first degree relative with a history of malignant hyperthermia
Has a known additional malignancy that is expected to require active treatment within two years, or is likely to be life-limiting in the opinion of the treating investigator. Superficial bladder cancer, non-melanoma skin cancers, or low-grade prostate cancer not requiring therapy would not exclude participation in this trial.
Uncontrolled intercurrent illness including, but not limited to: Symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
Pregnant or lactating females
* Patients who undergo reoperation during their initial hospitalization will be censored at the time of reoperation.
