Study of MTB-9655, an Inhibitor of ACSS2, in Patients With Advanced Solid Tumors

Exclusion Criteria

• •Patients who meet any of the following criteria will be excluded from study entry:
• •1. Treatment with any of the following:
• •* Any systemic anti-cancer chemotherapy, small molecule, biologic, or hormonal agent from a previous treatment regimen or clinical study within 28 days or 5 half-lives (whichever is shorter) prior to the first dose of study drug. At least 10 days must have elapsed between the last dose of such agent and the first dose of study drug.
• •* Wide-field radiotherapy administered ≤28 days or limited field radiation for palliation ≤7 days prior to starting study drug.
• •* Major surgery(excluding placement of vascular access) within 3 weeks of first dose of study drug.
• •* Prior treatment with other drug with the same mechanism of action (directed to ACSS2).
• •* Receiving systemic corticosteroid therapy 1 week prior to the first dose of study drug or receiving any other form of systemic immunosuppressive medication for medically significant acute or chronic conditions.
• •2. Persistent toxicity of National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Grade \>1 severity that is related to prior therapy.
• •3. Central nervous system tumor, metastasis(es), and/or carcinomatous meningitis identified either on the baseline brain imaging obtained during the screening period or identified prior to consent.
• •4. Active infection requiring treatment.
• •5. Out-of-range laboratory values defined as:
• •* Absolute neutrophil count (ANC) \<1.5 × 10\^9/L
• •* Hemoglobin \<9 g/dL
• •* Platelets \<100 × 10\^9/L)
• •* Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) \>2.5 × the upper limit of normal (ULN) or ≥5 × ULN with liver involvement
• •* Total bilirubin \>1.5 × ULN
• •* Serum creatinine \>1.5 × ULN or creatinine clearance (CrCl≤60mL/min, measured or calculated using the Cockcroft-Gault Method
• •* International Normalized Ratio (INR) or prothrombin time (PT) \>1.5 × ULN and activated partial thromboplastin time (aPTT) \>1.5 × ULN (unless patient is receiving anticoagulant therapy)
• •6. Inability to swallow oral medications or presence of active gastrointestinal disease or other condition that will interfere significantly with the absorption, distribution, metabolism, or excretion of MTB-9655 (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea Grade ≥2, malabsorption syndrome).
• •7. Any of the following cardiac criteria:
• •* Known history of marked prolongation of QT/corrected QT(QT/QTc) interval.
• •* Clinically significant cardiovascular disease, including cerebral vascular accident/stroke or myocardial infarction within 6 months of enrollment, unstable angina, congestive heart failure,or serious uncontrolled cardiac arrhythmia requiring medication.
• •* History of additional risk factors for Torsade de Pointes (including heart failure, hypokalemia, family history of long QT syndrome, and use of concomitant medications that prolong the QT/QTc interval.
• •* Patients with a left ventricular ejection fraction (LVEF) \<50%.
• •8. History of concomitant malignancy with recurrence \<3 year from enrolment.
• •9. Expected to require any other form of systemic or localized antineoplastic therapy while on trial.
• •10. Significant liver cirrhosis defined as Child-Pugh Class B or C.
• •11. History of hemolytic disorders.
• •12. Active infection with human immunodeficiency virus (HIV).
• •13. History or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the patient's participation for the full duration of the study, or is not in the best interest of the patient to participate, in the opinion of the treating Investigator.
• •14. Pregnant or breastfeeding.