Nous-PEV: a Novel Immunotherapy for Lung Cancer and Melanoma

Overall Study Design: • This is an open-label, non-randomized, dose-confirmation and cohort expansion phase 1b first-in-human study, in which 28 patients, expandable up to 34 evaluable patients in case of DLT. Study IMPs: Nous-PEV vaccine is composed of 2 sets of IMPs: * GAd-PEV * MVA-PEV Treatment phases: A) Induction phase with pembrolizumab (cycles 1, 2 and 3). B) Priming phase including 1 GAd-PEV administration with pembrolizumab (cycle 4). C) Boosting phase including 3 boosting administrations of MVA-PEV with pembrolizumab (cycles 5, 6 and 7).