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Comparing a Direct Versus an Indirect Approach to Measuring the Portalsytemic Pressure Gradients | Clinical Trials | Clareo Health

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Comparing a Direct Versus an Indirect Approach to Measuring the Portalsytemic Pressure Gradients

Endoscopic Ultrasound-Guided Portosystemic Pressure Gradient Measurements vs. Transjugular Balloon Occlusion Measurement: A Multicenter EU Study

NCT04987034•Cook Research Incorporated

View on ClinicalTrials.gov

Summary

The objective of this study is to evaluate the correlation of the calculated portosystemic pressure gradient (PPG) obtained by direct portal and hepatic pressure measurements with the EchoTip® Insight™ and indirect portal vein pressure measurements using the interventional radiology based hepatic venous pressure gradient (HVPG) procedure.

Eligibility

Age

18 - 85 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients with cirrhosis who have been referred for a procedure where HVPG is obtained.

Exclusion Criteria

•Patient is pregnant, breast-feeding, or planning to become pregnant during the course of the study
•Patient is unwilling or unable to sign and date the informed consent
•Patient is unwilling to comply with the follow-up study schedule
•Previous total or partial splenectomy
•Non-cirrhotic portal hypertension
•Known history of spontaneous bacterial peritonitis (SBP) within the last three months irrespective of treatment for SBP
•Patients with known infection which is not controlled by medical intervention
•Portopulmonary hypertension
•Cardiac decompensation
•Pre-sinusoidal liver disease
+3 more criteria

Locations (3)

University Hospitals Leuven

Leuven, Belgium

Erasmus University Medical Center

Rotterdam, Netherlands

Hospital Clinic, Barcelona

Barcelona, Spain

Key Dates

Start Date

July 27, 2021

Primary Completion Date

August 31, 2023

Completion Date

September 30, 2023

Last Updated

January 16, 2024

Enrollment

ACTUAL participants

Conditions

Liver Cirrhosis

Interventions

EchoTip® Insight™

DEVICE

Verification of Risk Factors of Thrombohemorrhagic Complications in Recipients After Related Liver Transplantation

NCT06169592

Liver CirrhosisLiver Transplant; Complications

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RECRUITING

Analysis of Methylomic Features and Prognostic Risk Prediction in Patients With Hepatitis B-related Acute-on-chronic Liver Failure

NCT07275554

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 16, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Comparing a Direct Versus an Indirect Approach to Measuring the Portalsytemic Pressure Gradients

Inclusion Criteria

Exclusion Criteria

Verification of Risk Factors of Thrombohemorrhagic Complications in Recipients After Related Liver Transplantation

Analysis of Methylomic Features and Prognostic Risk Prediction in Patients With Hepatitis B-related Acute-on-chronic Liver Failure

Validation of New Prognostic Biomarkers in Patients With Decompensated Cirrhosis

Stop of Proton-pump Inhibitor Treatment in Patients With Liver Cirrhosis - a Double-blind, Placebo-controlled Trial

DOAC in Patients with Child a or B Liver Cirrhosis

Role of Nutritional Intervention for the Treatment of Sarcopenia in Cirrhotic Patients with Refractory Ascites Candidate to Transjugular Intrahepatic Portosystemic Shunt Placement and Identification of Prognostic Factors Related to Clinical Outcome