Irradiation of Melanoma in a Pulse

Inclusion Criteria

• •1. Signed study Informed Consent Form
• •2. Karnofsky Performance Status (KPS) ≥ 50
• •3. Age ≥ 18 years
• •4. Patients with metastatic melanoma and multiple skin metastases with a documented clinical progression despite the systemic treatments (chemotherapy, and/or Programmed cell death 1 (PD1), cytotoxic T-lymphocyte antigen-4 (CTLA4) inhibitors or tyrosine kinase inhibitors (TKIs), such as v-raf murine sarcoma viral oncogene homolog B1 (BRAF) or mitogen-activated extracellular signal-regulated kinase (MEK) inhibitors)
• •5. The size of the treated lesions should be ≤ 5.5 cm in diameter and ≤ 2.8 cm thick (caliper-based measurement)
• •6. The treated lesions should be at least 5 cm apart and must not be located on the face.
• •7. Women of childbearing potential (WOCBP) must have a negative serum or urine pregnancy test (urine or serum) during screening
• •8. WOCBP must use a contraceptive method