Opioid Antagonism in Hypogonadotropic Hypogonadism

You may be eligible if

• Inclusion
• Male
• Age 18-75 years
• Confirmed diagnosis of hypogonadotropic hypogonadism (low testosterone)
• All medical conditions stable
• Normal blood pressure (systolic BP \< 140 mm Hg, diastolic \< 90 mm Hg)
• Negative urine drug screening panel
• Hemoglobin
• Men on adequate testosterone replacement therapy: normal male reference range
• Men off testosterone replacement therapy: no lower than 0.5 gm/dL below the lower limit of the reference range for normal women
• Exclusion
• Any condition (medical, mental, or behavioral) that, in the opinion of a study investigator, would likely interfere with participation in/completion of the protocol
• Current or recent use of a medication (including hormonal replacement) that, in the opinion of a study investigator, can modulate the reproductive axis and, if applicable, unwilling to complete an appropriate washout for that particular medication and its method of administration
• Current or recent use of a medication that affects the opioid pathway
• Active illicit drug use