Clinical Trial to Determine the Effect of a Mouthwash on the Preservation of the Ecology of the Oral Microbiome and Its Compatibility With Health

Exclusion Criteria

• •with periodontitis in the month prior to inclusion;
• •with significant carious lesions deeply modifying the oral microbiota in the month prior to inclusion;
• •having undergone oral surgical treatment within 3 months prior to inclusion;
• •wearing orthodontic appliances;
• •having undergone periodontal procedures in the month prior to inclusion;
• •suffering from severe chronic pathologies deemed incompatible with study entry;
• •allergic to one of the swab components;
• •allergic to any of the components of the BUCCOTHERM mouthwash or the placebo;
• •on drugs that may cause gingival hypertrophy, such as Hydantoins (phenytoin), Dihydropyridines, Diltiazem or Ciclosporin;
• •Medications that can cause gingival bleeding (anticoagulants, antiplatelet agents and aspirin);
• •Antibiotic therapy or professional scaling in the month prior to inclusion;
• •having used oral or topical antibiotics, antiseptics and/or antifungals (e.g., mouthwash, dental gels, etc.) in the month prior to inclusion.
• •Subjects with poor written and spoken French language skills;
• •previously included in the BUCCOTHERM study;
• •simultaneously participating in another trial that may interfere with the conduct of the BUCCOTHERM study or in a period of exclusion after participation in another clinical study;
• •protected persons (adults under legal protection (legal guardianship, curatorship, tutorship), persons deprived of liberty, pregnant or breastfeeding women, women of childbearing age without effective contraception (estrogen-progestin treatments, IUD, tubal ligation), minors.