Application of Pablizumab Combined With Apatinib and Chemotherapy in Resectable Non-small Cell Lung Cancer： A Prospective, Single Arm, Single Center Phase II Clinical Study of Neoadjuvant Therapy

Exclusion Criteria

• •Or radiotherapy;
• •2\. The tumor has invaded important blood vessels or the tumor is in the treatment stage according to the judgment of the researcher
• •There is a high possibility of invading important blood vessels and causing massive hemorrhage;
• •3\. Known EGFR mutation or ALK gene translocation;
• •4\. There are locally advanced unresectable diseases and metastatic diseases;
• •5\. She had been suffering from the need to use corticosteroids (prednisolone) in 14 days before randomization
• •Daily dose of nisone or equivalent (10 mg) or other immunosuppressive drugs
• •Any disease requiring systemic treatment. Local replacement steroids are permitted
• •(daily dose ≤ 10 mg of prednisone or equivalent) and prescription corticosteroids
• •Short term (≤ 7 days) prophylactic use of alcohol or for the treatment of non autoimmune.
• •Any active autoimmune disease or history of autoimmunity;
• •6\. Active autoimmune diseases or autoimmune diseases that may recur
• •History. Admission of well controlled type I diabetes and hormone replacement therapy are allowed.
• •Hypothyroidism, well controlled celiac disease, and no need for complete treatment
• •Skin diseases (such as vitiligo, psoriasis or alopecia) treated by the body or not
• •Due to the absence of recurrence of the disease is not expected.
• •7\. Interstitial lung disease, non infectious pneumonia or poorly controlled diseases (including pulmonary fibrosis)
• •History of vitamin C, acute lung disease, etc.
• •8\. active hepatitis B (defined as screening hepatitis B virus surface antigen \[HBsAg\])
• •The results were positive and HBV-DNA was detected. The detection value was higher than that in the study
• •Upper limit of normal value of cardiology laboratory) or hepatitis C (defined as screening hepatitis C virus table)
• •The subjects with positive results of hcsab and HCV-RNA;
• •9\. Known human immunodeficiency virus (HIV) infection (known HIV antibody positive);
• •10\. Inoculate live vaccine within 30 days before the first administration. Including but not limited to the following:
• •Mumps, rubella, measles, varicella / herpes zoster (varicella), yellow fever
• •Rabies, BCG and typhoid vaccine (inactivated virus vaccine allowed);
• •11\. Suffering from uncontrolled clinical symptoms or diseases of the heart;
• •12\. Long term antiplatelet therapy is needed;
• •13\. Those who are allergic to any drug in this program;
• •14\. Pregnant or lactating women;
• •15\. According to the judgment of the researcher, the subjects may confuse the test results and interfere
• •It is not in the best interests of the subjects to participate in the whole trial
• •A history or current evidence of any disease, treatment, or laboratory abnormality
• •It's a good idea.
• •16\. Active bleeding.
• •Exclusion criterion:
• •1. Ever received any treatment including chemotherapy or radiotherapy in the past;
• •2. The tumor has invaded important blood vessels. There is a high possibility of invading important blood vessels and causing massive hemorrhage if the tumor is in the treatment stage process according to the judgment of the researcher;
• •3. EGFR mutation or ALK gene translocation;
• •4. There are locally advanced unresectable diseases and metastatic diseases;
• •5. Patients had been suffering from the need to use corticosteroids (prednisolone) in 14 days before randomization grouping. Daily dose of nisone or equivalent (10 mg) or other immunosuppressive drugs. Any active autoimmune disease or history of autoimmunity;
• •6. Active autoimmune diseases or autoimmune diseases that may recur
• •7. Interstitial lung disease, non infectious pneumonia or poorly controlled diseases (including pulmonary fibrosis) etc.
• •8. active hepatitis B (defined as screening hepatitis B virus surface antigen \[HBsAg\]). And the results were positive and HBV-DNA was detected. The detection value was higher than that in the study upper limit of normal value of cardiology laboratory) or hepatitis C (defined as screening hepatitis C virus table and the subjects with positive results of hcsab and HCV-RNA;
• •9. Known human immunodeficiency virus (HIV) infection (known HIV antibody positive);
• •10. Inoculated live vaccine within 30 days before the first administration. Including but not limited to the following: Mumps, rubella, measles, varicella / herpes zoster (varicella), yellow fever Rabies, BCG and typhoid vaccine (inactivated virus vaccine allowed);
• •11. Suffering from uncontrolled clinical symptoms or diseases of the heart;
• •12. Long term antiplatelet therapy is needed;
• •13. Those who are allergic to any drug in this program;
• •14. Pregnant or lactating women.;
• •15. According to the judgment of the researcher, the subjects may confuse and interfere the test results. It is not in the best interests of the subjects to participate in the whole trial.
• •16. Active bleeding patients.