Functional and Structural Lung Imaging in Chronic Obstructive Pulmonary Disease

Inclusion Criteria

• •Male or female aged 18 years and over
• •Capacity to give informed consent
• •Normal blood pressure (systolic BP \> 90 mmHg and diastolic BP \>50 mmHg)
• •Resting heart rate \> 50bpm
• •For women, negative urinary β-hCG at the screening and subsequent visits (where clinical uncertainty of pregnancy)
• •Subject able to hold breath for 10 seconds
• •Subject able to understand the requirements of the study and to cooperate with the study procedures
• •Subject has normal lung function by spirometry criteria
• •Smoking history of \> 10 pack years of tobacco smoking
• •Male or female aged 18 years and over
• •Capacity to give informed consent
• •Normal blood pressure (systolic BP \> 90 mmHg and diastolic BP \>50 mmHg)
• •Resting heart rate \> 50bpm
• •For women, negative urinary β-hCG at the screening and subsequent visits (where clinical uncertainty of pregnancy)
• •Subject able to hold breath for 10 seconds
• •Subject able to understand the requirements of the study and to cooperate with the study procedures
• •Diagnosis of COPD made by respiratory physician and confirmed by spirometry criteria (FEV1/FVC ratio \< 0.7) and \> 10 pack years of tobacco smoking.
• •Male or female aged 18 years and over
• •Capacity to give informed consent
• •Normal blood pressure (systolic BP \> 90 mmHg and diastolic BP \>50 mmHg)
• •Resting heart rate \> 50bpm
• •For women, negative urinary β-hCG at the screening and subsequent visits (where clinical uncertainty of pregnancy)
• •Subject able to hold breath for 10 seconds
• •Subject able to understand the requirements of the study and to cooperate with the study procedures
• •Diagnosis of A1ATD (PiZZ or PiZ-) and either evidence of emphysema on a previous clinical CT scan or evidence of airways obstruction