Closed-loop Oxygen Control for High Flow Nasal Therapy

Exclusion Criteria

• •Patient with indication for immediate continuous positive airway pressure (CPAP), noninvasive ventilation (NIV), or invasive mechanical ventilation
• •Hemodynamic instability defined as a need of continuous infusion of epinephrine or norepinephrine \> 1 mg/h
• •Low quality on the SpO2 measurement using finger and ear sensor (quality index below 60% on the Massimo SpO2 sensor, which is displayed by a red or orange colour bar)
• •Severe acidosis (pH ≤ 7.30)
• •Pregnant woman
• •Patients deemed at high risk for need of mechanical ventilation within the next 8 hours
• •Chronic or acute dyshemoglobinemia: methemoglobin, carbon monoxide (CO) poisoning, sickle cell disease
• •Tracheotomised patient
• •Formalized ethical decision to withhold or withdraw life support
• •Patient under guardianship
• •Patient deprived of liberties
• •Patient included in another interventional research study under consent
• •Patient already enrolled in the present study in a previous episode of acute respiratory failure