HAIC With FOLFOX Versus Systemic Chemotherapy With GP for Unresectable ICC

Inclusion Criteria

• •The diagnosis of ICC
• •Patients must have at least one tumor lesion that can be accurately measured according to mRECIST criteria.
• •With no previous treatment
• •No Cirrhosis or cirrhotic status of Child-Pugh class A only
• •Not amendable to surgical resection ,local ablative therapy and any other cured treatment.
• •Without distant metastasis, but intrahepatic lymph node metastasis is allowed
• •The following laboratory parameters:
• •Platelet count ≥ 50,000/μL Hemoglobin ≥ 8.5 g/dL Total bilirubin ≤ 30mmol/ L Serum albumin ≥ 32 g/L ASL and AST ≤ 6 x upper limit of normal Serum creatinine ≤ 1.5 x upper limit of normal INR ≤ 1.5 or PT/APTT within normal limits Absolute neutrophil count (ANC) \>1,500/mm3