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COMPLETEDNCT04960059

NOTION: iN-home Sampling Of cyTokines in ImmunOtherapy patieNts

This study will explore the ability of patients on first line combination immunotherapy to sample cytokines at home. The data from this study will be used to evaluate the feasibility of in-home testin...

Lead sponsor: The Christie NHS Foundation Trust•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

The Christie NHS Foundation Trust

Collaborators

University of Manchester

Patients will be informed of the study and given a minimum of 24 hours to consider. Once consented patients will enter the study where they will take cytokine samples at home over a 12 week period.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Voluntary informed consent.
•Aged at least 18 years.
•Diagnosis of locally advanced or metastatic RCC, Melanoma or NSCLC
•In the opinion of the investigator deemed suitable to receive first-line combination immunotherapy (RCC and MM) or combination immunotherapy and chemotherapy (NSCLC).
•Willingness to comply with scheduled trial procedures.
•Capable of performing own dry blood sampling procedure, or a carer who is willing and able to perform them.

Exclusion Criteria

•Previous immunotherapy (including any CPI either as single agent on in combination, or high dose interleukin-2).
•Judgement by the investigator that the individual should not participate if they are unlikely to comply with study procedures and requirements.
•Patients receiving long term oral anticoagulation deemed by the clinician to be at risk from daily finger pricking.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 19, 2026Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment24

Start dateFeb 2022

Last updatedMar 19, 2026

Condition

Cancer Metastatic Melanoma Renal Cell Carcinoma Non-small Cell Lung Cancer

Locations shown

The Christie NHS Foundation Trust

Manchester

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 19, 2026Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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