Fractionated CO2 Laser With and Without Clobetasol for Treatment of Vulvar Lichen Sclerosus

Exclusion Criteria

• •Prior surgery with placement vaginal mesh for repair of pelvic organ prolapse (does not include vaginal mesh for anti-incontinence procedure "sling" or prior mesh sacrocolpopexy)
• •Prior laser, topical immunomodulators or systemic therapy for LS
• •Active genital infection\^
• •Suspicious vulvar lesion that has not been evaluated
• •Known vulvar or vaginal malignancy or active treatment for other malignancy
• •Planning pregnancy or pregnant
• •Prior pelvic radiation therapy
• •Topical corticosteroid use on the vulvovaginal tissues in the past 2 weeks\*
• •Contraindication or allergy to clobetasol propionate 0.05%
• •Currently breast-feeding or lactating
• •History of poor wound healing, keloids or hypertrophic scarring
• •History of a skin condition that could interfere with evaluation of efficacy and safety
• •* Eligible for inclusion after washout period of 2 weeks \^Eligible for inclusion after treatment. For patients with known genital HSV we will instruct them to remain on suppression for the duration of the study.