Age

18–69

Sex

ALL

Healthy volunteers

Not accepted

Myocardial infarction or stroke within the last 6 months
unstable angina, symptoms of angina within the last 3 months
NYHA class III or IV heart failure or LVEF \< 30%
poorly controlled hypertension: SBP \> 180 mm Hg or DBP \> 110 mm Hg,
pregnancy,
evidence of a previous acute coronary syndrome,
current smokers,
individuals with Type 2 Diabetes Mellitus, obesity (BMI \> 30),
hypertriglyceridemia (fasting TG \> 250 mg/dl),
renal insufficiency (Cr \> 1.8),
hepatic disease (aspartate aminotransferase(AST) or alanine aminotransferase (ALT) \> 2x ULN),
hypothyroidism,
nephrotic syndrome,
rheumatoid arthritis,
systemic lupus erythematosus,
AIDS or HIV
history of malignancy of any organ in last 5 years.

2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)