Efficacy and Safety of Losartan/Chlorthalidone vs Losartan/Hydrochlorothiazide in Essential Arterial Hypertension

Exclusion Criteria

• •The drug is contraindicated for medical reasons.
• •Glomerular filtration rate ≤30 ml / min x 1.73 m2.
• •Hypersensitivity to any of the components of the formula or other sulfonamides.
• •Patients treated with other diuretics.
• •Patient with a history of vascular disease (cerebrovascular disease, acute coronary syndrome, etc.) and acute renal failure in the last 6 months.
• •Patient with severe complications of type 2 diabetes mellitus (Ketoacidosis or hyperosmolar nonketotic coma).
• •Patients participating in another clinical study involving an investigational treatment or participated in one in the previous 4 weeks.
• •Positive pregnancy test, women who are pregnant, breastfeeding or planning a pregnancy while conducting the study.
• •Oncological patients (except basal cell skin cancer) or with serious diseases that, in the opinion of the investigator, have a serious prognosis or a life expectancy of less than 1 year, as well as mental illnesses.
• •Patients diagnosed with gout.
• •Patients whose participation in the study may be influenced (employment relationship with the research center or sponsor, inmates, etc.).