Motor Asymmetry in Progressive Multiple Sclerosis Patients

You may be eligible if

• 1.1/ Patients:
• * Aged between 18 and 60 years.
• * Primary Progressive Multiple Sclerosis or Secondary Progressive Multiple Sclerosis as defined by Mac Donald revised criteria in 2017.
• * Expanded Disability Status Scale lower or equal to 8.0, at inclusion.
• * asymmetric motor deficit. The motor deficit asymmetry will be defined by a difference of 3 or more at the American Society Injury. Association motor sub-score per limb between the right lower limb and the left lower limb.
• * No evidence of focal inflammatory activity for at least 3 years (no clinical relapse, no gadolinium enhancement on an Magnetic Resonance Imaging scan and no new T2 lesion)
• * Provided written informed consent according to the Institutional review board approval
• * Affiliated to the French healthcare system.
• 1.2 / Controls:
• * Aged between 18 and 60 years, sex and age matched with patients.
• * Provided written informed consent according to the Institutional review board approval
• * Affiliated to the French healthcare system.
• 2.1 /Patients:
• cerebellar Expanded Disability Status Scale sub score higher than pyramidal Expanded Disability Status Scale sub score.
• Relapse or corticosteroids in the 30 days preceding inclusion.
• Other neurological diseases.
• Lack of ability to understand the Institutional review board consent form.
• Magnetic Resonance contraindications.
• Pregnancy and breastfeeding.
• Major persons subject to legal protection (legal safeguards, guardianship,curatorship), persons deprived of their liberty
• 2.2 / Controls:
• Personal history of central nervous related disease
• Familial history of Multiple Sclerosis.
• Personal history of spinal cord injury.
• Personal history of spondylotic myelopathy.
• Magnetic Resonance Imaging contraindication.
• Lack of ability to understand the Institutional review board form.
• Major persons subject to legal protection (legal safeguards, guardianship, curatorship), persons deprived of their liberty
• Pregnancy and breastfeeding.