Motor Asymmetry in Progressive Multiple Sclerosis Patients

Inclusion Criteria

• •1.1/ Patients:
• •* Aged between 18 and 60 years.
• •* Primary Progressive Multiple Sclerosis or Secondary Progressive Multiple Sclerosis as defined by Mac Donald revised criteria in 2017.
• •* Expanded Disability Status Scale lower or equal to 8.0, at inclusion.
• •* asymmetric motor deficit. The motor deficit asymmetry will be defined by a difference of 3 or more at the American Society Injury. Association motor sub-score per limb between the right lower limb and the left lower limb.
• •* No evidence of focal inflammatory activity for at least 3 years (no clinical relapse, no gadolinium enhancement on an Magnetic Resonance Imaging scan and no new T2 lesion)
• •* Provided written informed consent according to the Institutional review board approval
• •* Affiliated to the French healthcare system.
• •1.2 / Controls:
• •* Aged between 18 and 60 years, sex and age matched with patients.
• •* Provided written informed consent according to the Institutional review board approval
• •* Affiliated to the French healthcare system.
• •2.1 /Patients:
• •cerebellar Expanded Disability Status Scale sub score higher than pyramidal Expanded Disability Status Scale sub score.
• •Relapse or corticosteroids in the 30 days preceding inclusion.
• •Other neurological diseases.
• •Lack of ability to understand the Institutional review board consent form.
• •Magnetic Resonance contraindications.
• •Pregnancy and breastfeeding.
• •Major persons subject to legal protection (legal safeguards, guardianship,curatorship), persons deprived of their liberty
• •2.2 / Controls:
• •Personal history of central nervous related disease
• •Familial history of Multiple Sclerosis.
• •Personal history of spinal cord injury.
• •Personal history of spondylotic myelopathy.
• •Magnetic Resonance Imaging contraindication.
• •Lack of ability to understand the Institutional review board form.
• •Major persons subject to legal protection (legal safeguards, guardianship, curatorship), persons deprived of their liberty
• •Pregnancy and breastfeeding.