Treatment Response Prediction System of mCRC Patients Based on CTC

Inclusion Criteria

• •Age 18-80 years;
• •histologically proven colorectal liver metastasis
• •With liver-dominant disease (extrahepatic metastases limited to lung metastases)
• •ECOG 0-1
• •A life expectancy of ≥ 3 months
• •Adequate hematologic function: absolute neutrophil count (ANC)≥1.5×109/l, platelets≥75×109/l, and international normalized ratio (INR) ≤1.3
• •Adequate liver and renal function: total bilirubin ≤2.0 mg/dl, alanine aminotransferase, aspartate aminotransferase ≤ 5x upper limit of normal, and albumin≥2.5 g/dl, serum creatinine≤2.0 mg/dl
• •Written informed consent for participation in the trial.