All-extremity Exercise During Breast Cancer Chemotherapy

You may be eligible if

• Active diagnosis of primary invasive non-metastatic breast cancer, stages I-III
• Female
• 18 to 85 years of age
• Scheduled to initiate neoadjuvant or adjuvant chemotherapy (anthracycline, alkylating agent and/or taxane)
• Absence of contraindications to exercise
• Study clinician approval
• Able to give consent
• Informed consent obtained from the subject and documentation of subject agreement to comply with study-related process
• Receiving targeted therapies (CDK4/6 or PARP inhibitors)
• Receiving radiation therapy concurrent with chemotherapy
• Lymphedema stage ≥ 2 prior to study enrollment
• Any relevant cardiovascular diseases (stroke, heart failure, myocardial ischemia during maximal graded exercise test, myocardial infarction, angina pectoris, coronary artery bypass surgery or angioplasty or coronary stent)
• Current participation in other experimental interventions that may confound interpretation of study findings (e.g., dietary intervention for weight loss)