CLearing Alzheimer's Disease Molecular Pathology Without Medications

Exclusion Criteria

• •history of epilepsy;
• •clinically relevant visual or auditory diseases/deficits;
• •clinical diagnosis of dementia;
• •contraindication to amyloid-PET;
• •inability to undergo the procedures of the study, e.g. severe behavioral disturbances;
• •severe diseases:
• •1. Malignant neoplasm within 5 years,
• •2. Life threatening diseases,
• •3. Severe systemic diseases (e.g. kidney insufficiency, cardiac insufficiency, decompensated diabetes, decompensated metabolic diseases, decompensated hypothyroidism, uncontrolled autoimmune diseases);
• •the participation to a clinical trial involving potential Alzheimer's disease modifying therapies;
• •documented pregnancy or intention to become pregnant during the course of the study or breast feeding.