Development of an Innovative Health Ingredient From Marine By-products for the Healthy Aging

Exclusion Criteria

• •Person who has participated in the last 3 months or is currently participating in another clinical trial that may interfere with the evaluation of the primary endpoint (memory).
• •Subject consuming food supplements likely to have an effect on memory or within less than 6 months
• •Subject consuming high level of Vitamin A and/or Long chain n-3 PUFA evaluated by a food frequency questionnaire
• •Restrictive or unbalanced diet (hypocaloric, vegetarian, vegan, …) self-declared at V0
• •Fish consumption more than twice a week
• •Allergy to fish
• •Life threatening pathology (such as cancer) in remission for less than 1 year or still ongoing,
• •Diabetes (type 1 or type 2),
• •Cardiovascular disease diagnosed within less that 2 years, with the following exceptions: subjects with controlled (medicated) high blood pressure and/ or controlled (medicated) can be included,
• •Personal history of stroke
• •Personal history of schizophrenia or other psychiatric disorders
• •Ongoing neuroleptic treatment
• •Current depressive episode characterized at clinical interview according to the criteria of module A of the MINI (Mini International Neuropsychiatric Interview)
• •Unbalanced thyroid disease (treatment modified in the last 6 months),
• •For women: hormone replacement therapy started less than 3 months ago or for which the dosage of the treatment has been modified in the last 3 months or whose dosage is likely to be modified during the study
• •Chronic inflammatory bowel disease or chronic disorders of intestinal absorption
• •Diagnosed inflammatory bowel disease or chronic intestinal absorption disorders
• •Current antidepressant treatment or discontinuation within the last 3 months
• •Substance abuse or alcoholism within the last 6 months (smoking is allowed)
• •General anesthesia in the last 6 months or scheduled in the next 6 months
• •Alcohol abuse: more than 2 standard drinks per day,
• •Subjects with clinical characteristics that may interfere with the performance of the tests (e.g.: acute visual or hearing impairment)
• •Person placed under court protection,
• •Person participating in another research study with an exclusion period still in progress ongoing,