Conduction System Pacing Optimized Therapy

Exclusion Criteria

• •Subject has persistent or permanent AF (Atrial Fibrillation)/AFL (Atrial Flutter)
• •Subject has 2nd or 3rd degree AV (Atrioventricular) Block
• •Subject has RBBB with no additional conduction block
• •Subject has intrinsic (non-paced) QRS width less than or equal to 120 ms
• •Subject experienced MI within 40 days prior to enrollment
• •Subject underwent valve surgery, within 90 days prior to enrollment
• •Subject is post heart transplantation or is actively listed on the transplantation list
• •Subject is implanted with a LV assist device
• •Subject has severe renal disease
• •Subject is on continuous or uninterrupted infusion (inotropic) therapy for heart failure
• •Subject has severe aortic stenosis (with a valve area of \<1.0 cm or significant valve disease expected to be operated within study period)
• •Subject has severe aortic calcification or severe peripheral arterial disease
• •Subject has complex and uncorrected congenital heart disease
• •Subject has mechanical heart valve
• •Pregnant or breastfeeding woman (pregnancy test required for woman of child-bearing potential and who are not on a reliable form of birth regulation method or abstinence)
• •Subject is enrolled in another study that could confound the results of this study without documented pre-approval from Medtronic study manager