Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study)

Exclusion Criteria

• •uncorrected hormone deficiency
• •creatinine \>1.5mg/dL
• •alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>2.5x upper limit of normal
• •hematocrit less than 30%
• •suicidality or active psychosis
• •participation in a trial with investigational drugs within 30 days
• •using a high glucocorticoid dose
• •vigorous physical exercise
• •alcohol intake within 24 hours before the study participation
• •evidence of any acute illness or any illness that the Investigator determines could interfere with study participation or safety
• •pregnancy or breastfeeding for last 8 weeks
• •known allergies towards CRH
• •patients refusing or unable to give written informed consent
• •Additionally for healthy controls: the presence of brain or pituitary tumor, radiation involving the hypothalamus or pituitary, history of hypopituitarism or receiving testosterone or glucocorticoids esters.