Meal Handling of Advanced Closed Loop Insulin Delivery.

Exclusion Criteria

• •1. Female subject who has a positive serum pregnancy screening test, or who plans to become pregnant during the course of the study
• •2. Subject has unresolved adverse skin condition, or unable to tolerate tape adhesive, in the area of sensor placement or device replacement (e.g., psoriasis, rash, Staphylococcus infection)
• •3. Subject has a history of hypoglycemic seizure or hypoglycemic coma within the past 12 months
• •4. Subjects currently taking adjunct therapy with SGLT2-inhibitors, Amylin.
• •5. Subject has a history of seizure disorder unrelated to diabetes within the past 12 months
• •6. Gastroparesis, uncontrolled thyroid disorder, Addison disease,. , Pituitary insufficiency
• •7. Subject has a history of myocardial infarction, unstable angina, coronary artery bypass surgery, coronary artery stenting, transient ischemic attack (TIA), cerebrovascular accident (CVA), congestive heart failure, ventricular rhythm disturbances, or thromboembolic disease within the past 6 months
• •8. Subject has a presence of a cardiac pacemaker or any other device that may be sensitive to radio frequency telemetry
• •9. Subject has any condition, including screening lab values that in the opinion of the Investigator may preclude him/her from participating in the study and completing study related procedures
• •10. Subject is actively participating in other investigational study (drug or device)
• •11. Subjects who consume alcohol daily
• •12. Use of CGM (other than per protocol) throughout the duration of the study
• •13. Use of Hydroxyurea medication