About Pricing FAQs Providers Blog

Loading clinical trials...

Your health journey, clearly organized.

Find Clinical Trials →

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

PFO Occlusion and Atrial Fibrillation | Clinical Trials | Clareo Health

Back to clinical trial search

UNKNOWNNANCT04898361

PFO Occlusion and Atrial Fibrillation

Interventional closure of patent foramen ovale (PFO) associates with reduced risk of stroke recurrence in patients with cryptogenic ischemic stroke as reported in the recent CLOSE and REDUCE trials. T...

Lead sponsor: University Hospital, Saarland•1 locations•View source on ClinicalTrials.gov

Clareo plain-language summary

What this study is about

Generating AI summary...

Save this trial guide to your notes

Keep your clinical trial research organized — questions to ask, what to expect, and key details.

Sponsors

Lead Sponsor

University Hospital, Saarland

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Previous embolic stroke with undetermined source with…
•palpitations with clinical indication for an electrophysiological study (control group)
•PFO and clinical indication for interventional PFO closure according to current guidelines (intervention group)
•Sinus rhythm at time of inclusion with no history of AF
•Planned EP study due to reported palpitations or documented burden of non-sustained atrial arrythymias (\>100 atrial ectopic beats /24 hours, atrial tachycardia)
•Written informed consent

Exclusion Criteria

•previously documented AF
•indication for therapeutic anticoagulation
•uncontrolled diabetes mellitus
•acute coronary syndrom or acute cardiac decompensation within the last 6 months before enrollment
•enrolled in another study
•BMI \> 40 kg/m²
•patients who are pregnant of breastfeeding life expectancy \< 6 months
•relevant peripheral artery disease
•substance abuse

Related studies

Pulmonary Embolism and Right-to-Left Shunts

NCT07519876 · Pulmonary Embolism (PE), Right-to-Left Shunt, and more

SENIOR: Stroke Prevention in the Elderly by Patent Foramen Ovale closuRe vs Anticoagulation

NCT07479147 · Ischemic Stroke, Embolic Stroke of Undetermined Source, and more

BurdEn of NEw Onset Atrial FIbrillation in patienTs With Acute Myocardial Infarction

NCT04528511 · Atrial Fibrillation New Onset, Acute Myocardial Infarction

Early Feasibility Study (EFS) Evaluating Percutaneous Repair of the Atrial Septum With a Novel PFO Occluder: The PROTEA-PFO Study

NCT07172464 · PFO, PFO - Patent Foramen Ovale, and more

Non-Invasive Detection of Right-to-Left Cardiac Shunts

NCT07420400 · Patent Foramen Ovale (PFO)

View all related studies →

Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 24, 2021Terms

Trial snapshot

StatusUNKNOWN

PhaseNA

Enrollment50

Start dateJan 2020

Last updatedMay 24, 2021

Condition

Atrial Fibrillation New Onset Embolic Stroke of Undetermined Source Patent Foramen Ovale

Locations shown

Universitätsklinikum des Saarlandes

Homburg, Saarland

For caregivers

Use Clareo to keep notes, questions, trial details, and next steps organized before and after appointments.

Start free trial →

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 24, 2021Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions