Does GLP-1RA Prevent Deterioration of Metabolic State in Prediabetic and Diabetic Patients Treated With Antipsychotic Medication?

Exclusion Criteria

• •1. Acute worsening of psychosis based on a clinical evaluation (score of 6 or 7 on the CGI-S scale)
• •2. Coercive measures
• •3. Females of child-bearing potential who are pregnant, breast-feeding or have intention of becoming pregnant.
• •4. Women who are not willing to use adequate contraceptive during the full length of the study
• •5. Patients treated with corticosteroids or other hormone therapy (except oestrogens)
• •6. Any active substance abuse or dependence for the past six months (except for nicotine)
• •7. Impaired hepatic function (plasma liver transaminases \>3 times upper normal limit)
• •8. Impaired renal function (serum creatinine \>150 μmol/l and/or macroalbuminuria)
• •9. Impaired pancreatic function (acute or chronic pancreatitis and/or plasma amylase \>2 times upper normal limit)
• •10. Cardiac problems defined as decompensated heart failure (NYHA class III/IV), unstable angina pectoris and/or myocardial infarction within the last 12 months
• •11. Hypertension with systolic blood pressure \>180 mmHg or diastolic blood pressure \>100 mmHg
• •12. Any condition that the investigator feels would interfere with trial participation
• •13. Receiving any experimental or pre-marketing drug within the last 3 months
• •14. Use of weight-lowering pharmacotherapy within the preceding 3 month
• •15. Known type 1 diabetes
• •16. Suicidal behavior as judged by the investigator and based on clinical evaluation. At all contact with patient attendance possible suicidality will be evaluated according to the guidelines. If the patient is evaluated as suicidal, the person will be excluded from the study and evaluated by a senior consultant in psychiatry, who will take further action.
• •17. Plasma HbA1c \> 57 mmol/mol (tested twice) in which case the patient will be excluded from the study and transferred to general practitioner or hospital for diabetic treatment. No diabetic medication is allowed except for the trial medicin.
• •18. Any known contraindication towards the treatment with semaglutide.