The researchers aim is to investigate the effects of disease modifying treatments on cognitive fatigue and on specific brain areas that have been shown to underlie cognitive fatigue in individuals with Multiple Sclerosis (MS). The researchers will investigate the effects on the cognitive fatigue that develops during the performance of a demanding task, and also on how cognitive fatigue changes as a function of duration of treatment.
Age
18–64
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Age between 18-64.
Relapsing remitting multiple sclerosis
Been newly prescribed a new disease modifying medication for MS (either Zeposia or other high dose oral efficacy medication)
or healthy volunteer who can speak English fluently.
You may not be if
History of head injury, stroke, seizures, or any other significant neurological event other than MS
Flare up of MS symptoms within the past month.
History of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder.
Pacemaker or other implanted electrical device, brain stimulator, aneurysm clip (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and internal hearing aids \[cochlear implants\]), permanent eyeliner, implanted delivery pumps, or shrapnel fragments.
left handed.
Not able to have an MRI
Clareo Health | An Examination of Cognitive Fatigue Using Functional Neuroimaging
