Indication of liver disease, defined by serum levels of either alanine aminotransferase (ALT), aspartate aminotransferase (AST) or alkaline phosphatase (ALP) above 3 x upper limit of normal (ULN) at screening
Haemoglobin \< 80 g/dL
Thrombocytopenia (platelet count \< 80000/mm\^3)
Prothrombin time International ratio (INR) \> 1.4
Pregnancy, or a positive pregnancy test
Ongoing daily treatment the last 3 days with non-steroidal anti-inflammatory drugs
Known active malignancy within the past 3 years
History of allergy/hypersensitivity to PD or ongoing allergy/hypersensitivity or history of hypersensitivity to drugs with a similar chemical structure or class to PDNO
History of any other clinically significant disease or disorder
Participation in any interventional clinical study
