A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of CKD-348(2)

Exclusion Criteria

• •1. Those who received investigational products or participated in bioequivalence tests within 6 months before the first administration of clinical trial drugs.
• •2. Those who take barbiturate and any related drugs which may cause induction or inhibition of drug metabolism within 1 month before the first administration of investigational products.
• •3. Those who donated whole blood or apheresis within 8 weeks or 4 weeks respectfully, or received blood transfusion within a month.
• •4. Those who have a history of gastrointestinal surgery except simple appendectomy and hernia surgery.
• •5. Those who exceed an alcohol and cigarette consumption than below criteria
• •* Alcohol: Man\_21 glasses/week, Woman\_14 glasses/week (1 glass: Soju 50mL, Wine 30mL, or beer 250mL)
• •* Smoking: 20 cigarettes/day
• •6. Those who have any history of diabetic mellitus, nephropathy, biliary obstruction, shock, angioedema, cardiac insufficiency, dihydropyridine sensitivity, unstable angina, hypothyroidism.
• •7. Those who have genetic problems such as galactose intolerance, Lapp lactose deficiency or glucose-galactose malabsorption.
• •8. Those who are deemed insufficient to participate in this clinical study by investigators.
• •9. Woman who are pregnant or breastfeeding.