Feasibility Study of Transcranial Ultrasound Stimulation (TUS) on Stroke Patients

Exclusion Criteria

• •severe heart failure (New York Heart Association class 4)
• •severe angina pectoris (canadian cardiovascular society class 4)
• •chronic kidney disease stage 5
• •hepatic encephalopathy stage 2 or more advanced
• •uncontrolled diabetes mellitus in recent 6 months (HbA1c \> 8.5)
• •combined with intraventricular hemorrhage causing hydrocephalus and underwent ventriculoperitoneal shunt placement surgery
• •high-dose radiation exposure in recent 1 year
• •blood flow of middle cerebral artery (M1) could be not be detected by transcranial doppler at either side
• •major psychological disease in recent 6 months (for example, uncontrolled depression, schizophrenia, and bipolar disease)
• •has evidence of any autoimmune disease, neurodegenerative disease (such as parkinsonism, Alzheimer's disease), or epilepsy
• •has clinically significant systemic disease or severe infection (pneumonia, sepsis)
• •pregnant or lactating women
• •allergy to MRI contrast
• •uncontrolled hypertension (systolic blood pressure higher than 160 mmHg or diastolic blood pressure higher than 100 mmHg) transcranial doppler
• •aneurysm, brain tumor, or arteriovenous malformation identified by MRA
• •has coagulation disorders or other coagulation problems identified by blood test (abnormal complete blood count, prothrombin time, or partial thromboplastin time)