Age

18–any

Sex

ALL

Healthy volunteers

Accepted

Common criteria for retrospective MS patients:
Patients aged 18 years or older
Clinical isolated syndrome (CIS) with or without dissemination in space
Patients affiliated to an appropriate health insurance
Criteria for Aggressive MS group
Start of a 2nd line therapy within the two years following the CIS
Criteria for Non aggressive MS group
No conversion according to McDonald criteria from clinical isolated syndrome to multiple sclerosis within 2 years or
Conversion based to McDonald criteria treated or not with first line disease modifying therapy within 2 years.
Have a minimum of least 2 years of follow-up.
Healthy volunteers
Aged 18 years or older
No history of clinically isolated syndrome or MS
Pairing criteria :
Age +/- 5 years
Sex
Prospective MS Patients
Patients aged 18 years or older
Clinical isolated syndrome (CIS) with or without dissemination in space
Patients affiliated to an appropriate health insurance

Ongoing participation to a another study
Refusal to genetic analyses
Immunosuppressive drug at the time of blood collection
Plasma exchange or corticosteroid treatment within the four weeks prior to blood sample
Adults under a legal protection regime (guardianship, trusteeship, judicial safeguard)
Pregnancy

From Genetics to Transcriptomics to Unravel the Mechanisms Behind a Poor Outcome in Multiple Sclerosis