Binimetinib and Palbociclib Before Surgery for the Treatment of Operable KRAS-Positive Lung, Colorectal, or Pancreatic Cancer

PRIMARY OBJECTIVE: I. To determine the on-target efficacy of binimetinib and palbociclib in patients with operable RAS-mutant lung adenocarcinoma, colorectal, or pancreatic cancer. SECONDARY OBJECTIVES: I. Correlative analysis of gene expression analysis. II. Define immune subsets within the pre and post-treatment tumor tissue. OUTLINE: Patients receive palbociclib orally (PO) once daily (QD) and binimetinib PO twice daily (BID) for 14 days in the absence of disease progression or unacceptable toxicity. Within 1 week after last dose of study medication, patients undergo surgery. After completion of study treatment, patients are followed up at 30 days.