Spot urine albumin:creatinine ≥30 mg/g unless on Renin-angiotensin-aldosterone system (RAAS) inhibition.
Ability to give informed consent.
You may not be if
Hemoglobin A1c greater than or equal to 11%.(in individuals with diabetes mellitus)
Anemia (hemoglobin less than 9g/dL)
Body weight greater than 150 kg or BMI greater than 50
Uncontrolled hypertension: sustained systolic blood pressure (SBP) greater than 155 mmHg at screening exam (a maximum of 3 screening visits will be allowed for demonstration of blood pressure control)
Chronic hypotension: sustained SBP less than 85 mmHg at screening exam.
Glomerulonephritis not in partial or complete remission for 6 months (or estimated/measured proteinuria greater than 10 grams/day)
Active glomerulonephritis (glomerular disease) include: ANCA associated glomerulonephritis, post-infectious glomerulonephritis, lupus nephritis, amyloidosis, or other monoclonal gammopathy of renal significance.
Nephrotic syndrome defined as proteinuria greater than 3.5g per 24 hours, plus hypoalbuminemia (serum albumin less than or equal to 2.5g/L) and edema
Autosomal dominant or recessive polycystic kidney disease
Active immunosuppression therapy (including prednisone greater than or equal to 10mg daily)
Kidney transplantation history
Solid organ transplantation history
Recent cardiovascular event (myocardial infarction, stroke, congestive heart failure) within 6 months or uncontrolled cardiac arrhythmias
Liver cirrhosis
Chronic obstructive pulmonary disease, asthma
History of blood clotting disorder (thromboembolism; pulmonary embolism, deep venous thrombosis)
Pregnancy
Active malignancy
Active infection
Active hepatitis B or C, or HIV infection
History of allergic reaction to cellular products (ie. blood transfusions, platelets)
Active tobacco use
Illicit drug use and excessive alcohol use presence of psychosocial issues (e.g., uncontrolled mental illness, unpredictable childcare or eldercare responsibilities, irregular/inflexible work schedule) that may interfere with the ability to complete all study procedures
Subjects anticipating prolonged travel or other physical restrictions that would prohibit return for scheduled study visits
Inability or unwilling to have magnetic resonance imaging (MRI) or computed tomography (CT) studies
