Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
King's College Hospital NHS Trust
With
King's College London
University of Leicester
Age
18–80
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Patients with established CKD (Stages 3-4) not on dialysis
Resting BP ≤ 160/95mmHg
Men and women aged 18 - 80 years
Serum ferritin level less than 100μg/L AND/OR transferrin saturation ≤20%
Haemoglobin 110 - 150 g/L
You may not be if
Pregnancy or breast feeding (Female patients of childbearing age will be asked if there is any possibility they may be pregnant. This is standard of care and no pregnancy test will be requested unless there is doubt about this. IV iron is given to many pregnant patients in standard treatment and there is no evidence of harm to mother or foetus).
Weight \< 50kg
Known allergy to iron therapy
Haemochromatosis, porphyria cutanea tarda or history of acquired iron overload
Intravenous iron within previous 6 weeks
CRP \> 50 mg/L
Serum phosphate \< 0.7 mmol/L.
Active infection
Current therapy with ESAs
Uncontrolled atrial fibrillation
Use of anticoagulants in those under consideration for muscle biopsy
Unstable angina or heart attack within the last year
Presence of solid organ cancer
Known haemoglobinopathy, myelodysplasia, or myeloma
Patients with peripheral vascular or musculoskeletal disease, who the investigator deems unable to carry out the 6MWT.
Known severe aortic stenosis and pacemaker in-situ
History of severe atopy
Severe liver disease with serum transaminases \> x3 upper limit of normal range according to local laboratory values.
Severe lung disease with FEV1 known to be \<50% predicted in last year
Known heart failure with a left ventricular ejection fraction \<45% in last year
Any other health condition considered by the local Principal Investigator in which IV iron will be contraindicated.
