AnalgeSiC and appEtite-stimulating Effects of caNnabigerol and THC (ASCENT)

Exclusion Criteria

• •Meeting DSM-V criteria for moderate-severe Cannabis Use disorder (CUD) or any substance use disorder other than nicotine, caffeine, or mild CUD
• •Any other Axis I disorder
• •• Current use of any medications within 14 days or 5 half-lives of administration (whichever is longer) except for hormonal contraceptives in females. If a medication is taken once a participant is enrolled, sessions will be suspended for 14 days or 5 half-lives after administration (whichever is longer)
• •If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process are not within the normal range and / or reveal any significant illness (e.g., hypertension) as judged by the study physician and to put the participant at greater risk of experiencing adverse events due to completion of study procedures.
• •Current pain
• •Pregnancy is exclusionary due to the possible effects of the study medication on fetal development.
• •History of an allergic reaction or adverse reaction to cannabis is exclusionary.
• •History of respiratory illness or current respiratory illness
• •Currently enrolled in another research protocol
• •Not using a contraceptive method (hormonal or barrier methods)
• •Insensitivity to the cold water stimulus of the Cold Pressor Test
• •Any disorders that might make cannabis administration hazardous are exclusionary, as determined by the evaluating physician