Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Amgen
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
* Men and women age ≥ 18 to ≤ 70 years of age at the time of signing the informed consent
* Body mass index (BMI) of ≥ 27 kg/m2 to ≤ 45.0 kg/m2
* Liver steatosis, measured by MRI-PDFF, greater than 8%
You may not be if
* Evidence of other liver disease (eg, viral hepatitis, primary sclerosing cholangitis, primary biliary cholangitis, autoimmune chronic hepatitis, Wilson's disease, alpha-1 anti-trypsin deficiency, haemochromatosis, drug-induced liver injury, bile duct obstruction, known or suspected hepatocellular carcinoma).
* Significantly elevated LFTs (more than 1.5x ULN)
* Uncontrolled diabetes (HgbA1c \> 9%) or uncontrolled hypertension.
* History of malignancy of any type, other than in situ cervical cancer or surgically excised non-melanomatous skin cancers occurring more than 5 years prior to randomization or 3 years prior to randomization for basal cell carcinoma.
* Females of reproductive potential.
Clareo Health | Single Ascending Dose of AMG 609 in Participants With Non-alcoholic Fatty Liver Disease
