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This study will use a randomized control trial (RCT) design to administer two versions of a multisession remote behavioral intervention for youth seeking Emergency Department care for a violent injury with the goal to reduce their violence involvement and associated negative behaviors and consequences. The study examines two versions of the remote therapy intervention - a standard RTI (S-RTI) and an Artificial Intelligence RTI (AI-RTI). The application of a just-in-time adaptive strategy to address youth violence is an important and novel direction for this research, particularly given the need to understand best practices for delivering behavioral interventions among lower-income populations.
The Specific Aims for the proposed study are to refine the Remote Therapy Intervention (RTI) for delivery using a standardized remote therapy package (S-RTI; 1 ED + 5 remote sessions) based on a piloted RTI and an adaptive RTI that optimizes bi-weekly dose and intervention intensity between four levels of therapy (remote therapy+, remote therapy; automated electronic tailored therapy; none) based on a reinforcement learning (RL) algorithm \[AI-RTI\]. A total of 750 youth (age=14-24) seeking ED care for a violent injury will be enrolled and randomly assigned (stratified by age/gender) to the S-RTI (n=250), AI-RTI (n=300), and a control (EUC; n=200) condition. In addition to the randomized assignment, all youth will take a daily assessment over the course of the intervention timeline. Outcomes will be assessed at 6 and 12 months.
Age
14 - 24 years
Sex
ALL
Healthy Volunteers
Yes
Grady Health System
Atlanta, Georgia, United States
Ascension St. John Hospital
Detroit, Michigan, United States
Hurley Medical Center
Flint, Michigan, United States
HUP and PPMC
Philadelphia, Pennsylvania, United States
Start Date
May 19, 2021
Primary Completion Date
March 31, 2026
Completion Date
March 31, 2026
Last Updated
October 29, 2025
584
ACTUAL participants
Remote Therapy Intervention (RTI)
BEHAVIORAL
Artificial Intelligence Remote Therapy Intervention
BEHAVIORAL
Lead Sponsor
University of Michigan
Collaborators
NCT04197921
NCT07199335
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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