Effects of Nicotinamide in Patients With Chronic Lymphocytic Leukemia With History of Non-melanoma Skin Cancers

Exclusion Criteria

• •Received cytotoxic chemotherapy (including fludarabine, cyclophosphamide, bendamustine, or chlorambucil) within the last 6 months
• •Received allogeneic stem cell transplant within the last 6 months.
• •Taking nicotinamide or niacin supplements within the last 4 weeks.
• •Taken acitretin or other oral retinoids within the past 6 months
• •Received field treatment for AKs (topical use of 5-fluorouracil, imiquimod, diclofenac, retinoids; topical photodynamic therapy for AKs; laser resurfacing or chemical peel treatments for AKs) within the previous 4 weeks
• •Large areas of confluent skin cancer at baseline preventing accurate assessment and counting of individual new skin cancers
• •Need for ongoing carbamazepine use (possible interaction with nicotinamide)
• •Severe GI malabsorption that may interfere with absorption of nicotinamide (per investigator's discretion)
• •Patients with an expected life expectancy \< 2 years
• •Current evidence of uncontrolled, diabetes.
• •Current evidence or history of peptic ulcer disease.
• •Known HIV infection with a detectable viral load within 6 months of the anticipated start of treatment.
• •Note: Subjects on effective antiretroviral therapy with an undetectable viral load within 6 months of the anticipated start of treatment are eligible for this trial.
• •Known active uncontrolled infection.
• •Medical, psychiatric, cognitive, or other conditions that may compromise the subject's ability to understand the subject information, give informed consent, comply with the study protocol or complete the study.
• •Known prior severe hypersensitivity to investigational product (IP) or any component in its formulations (NCI CTCAE v5.0 Grade ≥ 3).
• •Subjects taking prohibited medications as described in study protocol. A washout period of prohibited medications for a period of at least five half-lives or as clinically indicated should occur before the start of treatment.
• •Have ever received a solid organ transplant and are currently taking immunosuppressive medications.