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TERMINATEDPhase 1/2NCT04842981

Interleukin-6 Inhibitors and Drug-drug Interactions in Patients With Rheumatoid Arthritis

With this study the investigators aim to assess if drug metabolism changes in patients with rheumatoid arthritis when an interleukin (IL)-6 inhibitor is initiated. Patients with rheumatoid arthritis ...

Lead sponsor: University of Southern Denmark•3 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Southern Denmark

Collaborators

Odense University Hospital
Esbjerg Hospital - University Hospital of Southern Denmark
King Christian X´Hospital for Rheumatic Diseases
Sygehus Lillebaelt
Odense Patient Data Explorative Network

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Active rheumatoid arthritis
•Age 18-75 years
•eGFR \> 30 mL/min
•absolute neutrophil count (ANC) ≥ 2 x 109 /L
•Platelet count \> 150 x 103 /μL (corresponding to \>150 x 109 /L)
•ALAT in the normal range or within 1.5x the upper limit of normal.
•Use of effective contraception (only woman of childbearing potential)
•Negative test for hepatitis and tuberculosis

Exclusion Criteria

•Known sensitivity to any of the medications used.
•Active severe infections
•Malignancy
•Diverticulitis
•Intake of medications which can influence the safety of the patient or the results of the study. Can include prescription medications, over-the-counter medications, herbal medicines or dietary supplements. Will be assessed by the investigators.
•Participation in other clinical intervention trials.
•Pregnancy or breastfeeding

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: January 25, 2023Terms

Trial snapshot

StatusTERMINATED

PhasePHASE1/PHASE2

Enrollment3

Start dateMay 2021

Last updatedJan 25, 2023

Condition

Arthritis, Rheumatoid Interaction

Locations shown

Hospital South West Jutland

Esbjerg, Region Syddanmark

Odense University Hospital

Odense, Region Syddanmark

Danish Hospital for Rheumatic Diseases

Sønderborg, Region Syddanmark

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 25, 2023Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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