A Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly

Exclusion Criteria

• •1. Treatment naïve or treatment-withdrawn acromegaly subjects
• •2. Prior treatment with paltusotine
• •3. Pituitary surgery within 24 weeks prior to Screening or history of pituitary radiation therapy
• •4. History or presence of malignancy except adequately treated basal cell and squamous cell carcinomas of the skin within the past 5 years
• •5. Use of any investigational drug within the past 30 days or 5 half-lives, whichever is longer
• •6. Known history of HIV, hepatitis B, or active hepatitis C
• •7. History of alcohol or substance abuse in the past 12 months
• •8. Any condition that in the opinion of the investigator would jeopardize the subject's appropriate participation in this study
• •9. Cardiovascular conditions or medications associated with prolonged QT or those which predispose subjects to heart rhythm abnormalities
• •10. Subjects with symptomatic cholelithiasis
• •11. Subjects with clinically significant abnormal findings during the Screening Period, or any other medical condition(s) or laboratory findings that, in the opinion of the Investigator, might jeopardize the subject's safety or ability to complete the study
• •12. Subjects currently taking pasireotide LAR (within 24 weeks prior to Screening) or pegvisomant, dopamine agonists (within 12 weeks prior to Screening), or short acting somatostatin analogs (within 12 weeks prior to first dose of study drug)