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Verticalization Robotic Exoskeleton DoC | Clinical Trials | Clareo Health

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Verticalization Robotic Exoskeleton DoC

Verticalization With Vestibular Stimulation for Patients With Severe Disorders of Consciousness: A Novel Application of a Robotic Exoskeleton

NCT04833543•Memorial Hermann Health System

View on ClinicalTrials.gov

Summary

Mobilization, specifically verticalization, has been shown to play a role in enhancing consciousness. Vestibular stimulation has the potential to influence the neural substrate of consciousness, but this modality has not been thoroughly explored. The primary aim of this study is to compare the influence of verticalization with and without vestibular input on level of consciousness in patients experiencing disorders of consciousness (DoC).

Eligibility

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. unresponsive wakefulness syndrome/vegetative state (UWS/VS) or minimally conscious state (MCS) following traumatic brain injury (TBI), intracerebral bleeding, ischemic infarction, or hypoxic brain injury
•2. Medical clearance by a physician
•3. 18-75 years old
•4. Mobilization into standing for at least 10 minutes without signs of orthostasis

Exclusion Criteria

•1. Time since injury less than 4 weeks or more than 6 months
•2. Mobilization into standing lasts more than 30 minutes
•3. Severe osteoporosis
•4. Muscle tone that prevents joint motion (Modified Ashworth Scale (MAS) 4)
•5. Unstable fractures
•6. Decubiti on areas contacted by robotic mobility device (i.e. heels, tibia, greater trochanter, ischial tuberosity, sacrum)
•7. Inability to fit device requirements\*
•* Height 4'8"-6'4", Weight 88-222 lbs., Hip Flexion 0-90˚, Knee Flexion 0-90˚, Plantigrade

Locations (1)

TIRR Memorial Hermann

Houston, Texas, United States

Key Dates

Start Date

April 21, 2021

Primary Completion Date

December 1, 2021

Completion Date

December 1, 2021

Last Updated

September 1, 2021

Enrollment

ESTIMATED participants

Conditions

Brain InjuriesDisorder of Consciousness

Interventions

Robotic Mobility Device (REX)

OTHER

Tilt Table

OTHER

Early Post-Traumatic Seizures Prevention Trial (E-PTS Trial)

NCT07072624

SeizuresTraumatic Brain Injuries+1 more

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RECRUITINGNA

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Disorder of ConsciousnessStroke

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 1, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Verticalization Robotic Exoskeleton DoC

Inclusion Criteria

Exclusion Criteria

Early Post-Traumatic Seizures Prevention Trial (E-PTS Trial)

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