Vitamin D and Cocaine Administration

Exclusion Criteria

• •A history of other substance dependence (except for nicotine). Positive urine toxicology for cannabis is accepted for the study unless there is evidence for dependence per Structured Clinical Interview for DSM-5 (SCID) interview. Positive urine toxicology for other drugs at screening will be repeated. If positive again and/or positive at admission, subjects will be excluded
• •\< 1 year of cocaine abuse/dependence
• •A primary DSM-5 Axis I major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, etc.) unrelated to cocaine as determined by the SCID-5
• •Medical comorbidities including serum calcium ( \> 10.5 mg/dl, serum phosphorus \> 4.2 mg/dl), hyperparathyroidism, kidney disease (e.g., Serum creatinine \> 1.3 mg/dl)
• •A history of significant and uncontrolled medical (e.g., cardiovascular, diabetic/metabolic) or neurological (e.g., cerebrovascular, seizures, traumatic brain injury) illness
• •A history of seizures
• •Current use of psychotropic/potentially psychoactive medications or medications that can have drug drug interactions with calcitriol, including over the counter Vitamin D products, thiazide diuretics, and calcium supplements, etc, as referenced in the package insert for calcitriol
• •Seeking treatment for drug abuse/dependence
• •Hypersensitivity to calcitriol
• •For females, physical or laboratory (HCG) evidence of pregnancy.