Anti-CD7 CAR-Engineered T Cells for T Lymphoid Malignancies Malignancies

Exclusion Criteria

• •1. Complicated with central system leukemia/lymphoma with active intracranial lesions;
• •2. Existing or preexisting CNS conditions, such as epileptic seizures, cerebrovascular ischemia/hemorrhage, dementia, cerebellar disease, or any CNS related autoimmune disease;
• •3. Symptomatic heart failure or severe arrhythmias;
• •4. Symptoms of severe respiratory failure;
• •5. Complicated with other types of malignant tumors;
• •6. Serum creatinine and/or urea nitrogen ≥ 1.5 times of normal value;
• •7. Suffer from sepsis or other uncontrollable infections;
• •8. Intracranial hypertension or brain consciousness disorder;
• •9. Severe mental disorders;
• •10. Have received organ transplantation (excluding bone marrow transplantation);
• •11. Female patients (fertile patients) had positive blood HCG test;
• •12. Hepatitis (including hepatitis B and C), AIDS and syphilis were screened positive;
• •13. Patients with graft-versus-host disease (GVHD) or who require immunosuppressant treatment;
• •14. The absolute value of lymphocytes was too low to manufacture CART cells;
• •15. Other conditions considered inappropriate by the researcher.