Subject is a male or a female aged ≥ 18 years

Have given their written consent to participate in the study

Use of artificial tears (AT), autologous serum or specific dry eye medications during the last 6 months prior to the selection

Willing to not use AT or autologous serum for the study duration

VAS scale for Dry Eye Symptom Score ≥ 40

Total CFS ≥ 5

Schirmer's test with anesthesia \< 10 mm/5min

Patients with Sjögren Syndrome

Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome