The Use of Expandeded Mesenchymal Stromal Cells (MSC) in Premature Ovarian Failure (POF) in Adult Humans

Exclusion Criteria

• •1. Currently breast-feeding
• •2. Has a history of, or evidence of current malignancy
• •3. Major mental health disorder that precludes participation in the study
• •4. Current or recent (within the past 2 weeks) use of the following medications: Oral or systemic corticosteroids, Hormones (estrogen, progestins, oral contraceptives), Danazol, anticoagulants, herbal or botanical supplements with possible hormonal effects. Washout will be allowed.
• •5. Type I or Type II diabetes mellitus, or if receiving antidiabetic medications
• •6. Significant anemia (Hemoglobin \<8 g/dL).
• •7. Untreated deep venous thrombosis, and/or pulmonary embolus
• •8. Known heart disease (New York Heart Association Class II or higher).
• •9. Known Liver disease (defined as Aspartate Aminotransferase (AST) or Alanine Aminotransferase (ALT)\>2 times normal, or total bilirubin \>2.5 mg/dL).
• •10. Known Renal disease (defined as Blood urea nitrogen (BUN)\>30 mg/dL or serum creatinine \> 1.6 mg/dL).
• •11. Clinically active autoimmune condition