Neural Correlates of tVNS

Exclusion Criteria

• •Presence of metallic prostheses, pacemakers, metal clips on blood vessels, metal parts in the eye, an intrauterine device, metal braces, tattoos and/or other metal objects;
• •History of major head trauma or head/brain surgery;
• •History of claustrophobia;
• •History of severe or chronic cardiovascular, respiratory, urogenital, gastrointestinal/ hepatic, haematological/immunologic, HEENT (head, ears, eyes, nose, throat), dermatological/connective tissue, musculoskeletal, metabolic/nutritional, endocrine, neurological/psychiatric diseases, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol;
• •Use of regular medication, including vitamin and iron supplementation, except oral contraceptives, within 14 days prior to start of the study;
• •Pregnancy, lactation, wish to become pregnant;
• •High alcohol consumption (\>15 alcoholic units consumed per week);
• •Using drugs of abuse;
• •Administration of investigational drugs or participation in any scientific intervention study which may interfere with this study (to be decided by the principle investigator), in the 180 days prior to the study;
• •Participants unable to provide informed consent
• •Participants with any systemic disease or medications that may influence the autonomic nervous system (e.g. beta-agonists or Parkinson's disease)
• •Current smokers or current use of nicotine in any other way (including E-cigarettes and patches)
• •History of clinical anxiety or depression, or a hospital anxiety or depression score \>8
• •Participants whom score 8 or more on the HADS-questionnaire at study commencement
• •Patient whom have cardiovascular conduction problems
• •Patient with cochlear implants